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The post-mortem revealed startling new info

The post-mortem revealed startling new info

The post-mortem revealed startling new info

Evaluation of uncovered tissue samples from 44 individuals who died of COVID-19 confirmed that the SAR-CoV-2 virus had unfold all through the physique, together with the mind, and endured for practically 8 months.

Evaluation of tissue samples from autopsies of 44 individuals who died of[{” attribute=””>COVID-19 shows that SAR-CoV-2 virus spread throughout the body—including into the brain—and that it lingered for almost 8 months. The study was published on December 14 in the journal Nature.

Scientists from the National Institutes of Health (NIH) tested samples from autopsies that were performed from April 2020 to March 2021. They conducted extensive sampling of the nervous system, including the brain, in 11 of the patients.

RNA and viable virus in various organs

All of the patients died with COVID-19, and none were vaccinated. The blood plasma of 38 patients tested positive for SARS-CoV-2, 3 tested negative, and plasma was unavailable for the other 3.

Thirty percent of the patients were female, and the median age was 62.5 years. Twenty-seven patients (61.4%) had three or more comorbidities. The median interval from symptom onset to death was 18.5 days.

Analysis showed that SARS-CoV-2, as expected, primarily infected and damaged airway and lung tissue. But the researchers also found viral RNA in 84 distinct body locations and bodily fluids, and in one case they isolated viral RNA 230 days after a patient’s symptoms began.

The researchers detected SARS-CoV-2 RNA and protein in the hypothalamus and cerebellum of one patient and in the spinal cord and basal ganglia of two other patients. But they found little damage to brain tissue, “despite substantial viral burden.”

“We demonstrated virus replication in multiple non-respiratory sites during the first two weeks following symptom onset.”

The investigators also isolated viable SARS-CoV-2 virus from diverse tissues in and outside the respiratory tract, including the brain, heart, lymph nodes, gastrointestinal tract, adrenal gland, and eye. They isolated virus from 25 of 55 specimens tested (45%).

The authors wrote, “We demonstrated virus replication in multiple non-respiratory sites during the first two weeks following symptom onset.”

They add, “Our focus on short postmortem intervals, a comprehensive standardized approach to tissue collection, dissecting the brain before fixation, preserving tissue in RNA later, and flash freezing of fresh tissue allowed us to detect and quantify SARS-CoV-2 RNA levels with high sensitivity by [polymerase chain reaction] and [in situ hybridization]and to isolate the virus in cell tradition from a number of non-respiratory tissues, together with the mind, which is a notable distinction in comparison with different research.”

Potential penalties of “lengthy COVID”

Senior examine creator Daniel Chertow, MD, MPH, stated on the NIH information launch that earlier than the work started, “SARS-CoV-2 was believed to be primarily a respiratory virus within the subject.”

Detecting the presence of the virus all through the physique — and sharing these findings with colleagues a yr in the past — helped scientists examine the hyperlink between extensively contaminated physique tissues and “long-term COVID,” or signs that persist for weeks and months after an infection.

“We hope to duplicate the information on the persistence of the virus and study the affiliation with long-term COVID.”

The examine was co-authored by Steven Hewitt, MD

A part of the NIH-funded Paxlovid RECOVER trial, which is anticipated to start in 2023, consists of increasing the publicity work outlined in Nature examine, in line with co-author Steven Hewitt, MD, PhD, who serves on the steering committee for Mission RECOVER. The findings within the RECOVER examine embrace individuals who have been vaccinated and contaminated with variants of concern – knowledge that weren’t out there in yesterday’s examine.

“We hope to duplicate the persistence knowledge and study the affiliation with long-term COVID,” Hewitt stated. “We have had about 85 instances in lower than a yr and we’re working to broaden that effort.”

Reference: “SARS-CoV-2 An infection and Persistence within the Human Physique and Mind at Post-mortem” Sydney R. Stein, Sabrina Ok. Romeli, Alison Grazioli, Jun-Yong Chung, Manmeet Singh, Claude Kwe Yinda, Clayton W. Winkler, Junfeng Solar, James M. Dickey, Chris Ilaya, Sung Hee Ko, Andrew P. Platt, Peter D. Burbelo, Marta Quezada, Stefania Pitaluga, Madeleine Purcell, Vincent J. Munster, Frieda Belinki, Marcos J. Ramos-Benitez, Eli A. Boritz, Isabella A. Lach, Daniel L. Herr, Joseph Rabin, Kapil Ok. Saharia, Ronson J. Madatil, Ali Tabatabai, Shahabuddin Soherwardi, Michael T. McCurdy, NIH COVID-19 Post-mortem Consortium, Karin E. Peterson, Jeffrey I. Cohen, Amy de Wit, Kevin M. Vanello, Steven M. Hewitt, David E. Kleiner and Daniel S. Chertov, December 14. Nature.
DOI: 10.1038/s41586-022-05542-y





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