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Pfizer and BioNTech launch Section 1 trial of mixture vaccine in opposition to COVID-19 and influenza

Pfizer and BioNTech launch Section 1 trial of mixture vaccine in opposition to COVID-19 and influenza

Pfizer and BioNTech have begun scientific trials of a vaccine in opposition to COVID-19 and influenza introduced Thursday.

A part 1 trial is being carried out in the USA involving 180 contributors between the ages of 18 and 64, with the primary participant receiving a dose this week, the businesses mentioned. Every participant can be noticed for six months.

PHOTO: In this Sept. 8, 2022 file photo, a teenager receives the Pfizer-BioNTech COVID-19 booster vaccine targeting the Omicron BA.4 and BA.5 subvariants at Skippack Pharmacy in Schwenksville, Pennsylvania.

On this Sept. 8, 2022, file photograph, an adolescent receives the Pfizer-BioNTech COVID-19 booster vaccine concentrating on the Omicron BA.4 and BA.5 subvariants at Skippack Pharmacy in Schwenksville, Pennsylvania.

Hannah Bayer/Reuters

“By combining each indications into one vaccine method, we goal to supply folks with an efficient technique to be immunized in opposition to two extreme respiratory illnesses with evolving viruses that require vaccine adaptation,” mentioned Dr. Ugur Sahin, CEO and co-founder of BioNTech. within the assertion.

The mixture vaccine relies on the at the moment out there bivalent COVID-19 booster and quadrivalent mRNA influenza vaccine, which is designed to guard in opposition to 4 completely different influenza viruses.

The part 1 trial will check the protection, immune response and optimum dose stage of the mix vaccine earlier than transferring to bigger trials. The information can even make clear the potential of mRNA vaccines to combat multiple pathogen, Sahin mentioned.

Analisa Anderson, senior vp and chief scientific officer of Pfizer’s vaccine analysis and growth division, known as it “an thrilling step in our ongoing journey with BioNTech as we work collectively to remodel infectious illness prevention all over the world.”

“Even with current seasonal flu vaccines, the severity of this virus is critical worldwide, inflicting 1000’s of deaths and hospitalizations every year,” she mentioned in a press release.

PHOTO: In this Sept. 9, 2022 file photo, a man receives a flu vaccine from a pharmacist during an event hosted by the Chicago Department of Public Health at the Southwest Senior Center in Chicago.

On this Sept. 9, 2022, file photograph, a person receives a flu vaccine from a pharmacist throughout an occasion hosted by the Chicago Division of Public Well being on the Southwest Senior Heart in Chicago.

Scott Olson/Getty Photographs

Analysis reveals that the effectiveness of the COVID-19 vaccine decreases over time, though it’s unclear whether or not each American will want an annual booster shot in opposition to COVID-19. Whereas scientists proceed to evaluate the necessity, a number of firms are working to create a single injection every fall that protects in opposition to each seasonal flu and COVID-19.

Along with Pfizer, pharmaceutical firms Moderna and Novavax have introduced plans to work on a mixture shot.

Moderna mentioned it expects to start scientific trials of a single-dose vaccine that mixes a COVID-19 booster and an influenza booster by the tip of the yr, hoping to have the vaccine out there for the 2023 season.

“We predict there is a actually massive alternative for us if we are able to carry to market a high-performance annual respiratory booster,” Moderna COE Stefan Bansel mentioned throughout the Sept. 9 investor assembly.

Final yr, Novavax participated in a Section 1/2 research to guage the protection, tolerability and immune response of a mixture vaccine utilizing the corporate’s seasonal influenza and COVID-19 vaccines. Section 2 validation is anticipated to start later this yr, the corporate mentioned in October.


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