Overweight teenagers lose 15% of physique weight in trial of repurposed diabetes drug

Overweight teenagers lose 15% of physique weight in trial of repurposed diabetes drug

A woman weighing kg
Enhance / A lady weighing kg

A redesigned sort 2 diabetes drug helped overweight youngsters lose important weight, cut back heart problems threat elements and enhance weight-related high quality of life throughout a 68-week scientific trial. reported this week within the New England Journal of Drugs.

The drug is semaglutide (commerce title Wegovy), which was first authorized for the remedy of sort 2 diabetes in 2017, however since then additionally has been proven to be useful for weight reduction in adults who’re overweight or chubby. The drug works by mimicking a hormone known as glucagon-like peptide-1 (GLP-1), which impacts areas of the mind that regulate urge for food and meals consumption, the Meals and Drug Administration defined in approving its use for weight reduction in adults.

New proof exhibits that it could additionally considerably assist youngsters battling weight problems and chubby to enhance their well being and outlook as they transfer into maturity. Each fifth baby and teenager weight problems within the U.S. may cause critical sicknesses in youngsters, together with hypertension, excessive ldl cholesterol, sort 2 diabetes, respiration issues and joint issues, in keeping with the Facilities for Illness Management and Prevention.

After all, semaglutide isn’t a magic remedy for weight problems, which is a posh, multifactorial, continual illness. The researchers word that in a seven-week follow-up after 68 weeks of remedy, some youngsters regained a small quantity of weight, suggesting that they might must proceed taking the drug to take care of weight reduction. It is also unclear how lengthy an individual can take the drug whereas nonetheless seeing weight reduction. Nonetheless, the drug could also be a helpful new software within the battle towards an intractable, progressive illness.

The outcomes

In a section 3, double-blind, randomized, placebo-controlled trial reported this week, researchers gave 12- to 17-year-olds 2.4 mg of semaglutide weekly for 68 weeks.

Of the 201 adolescents within the research, 133 overweight adolescents and one chubby adolescent obtained semaglutide, and 67 obtained a placebo. Each teams, together with mother and father and guardians, additionally obtained counseling on wholesome consuming and train.

The drug seemed to be typically secure, with some gastrointestinal uncomfortable side effects – nausea, vomiting and diarrhea – largely seen early in remedy, which tended to decrease over the weeks.

After 68 weeks, these receiving semaglutide misplaced a mean of about 15 p.c of their preliminary weight, about 34 kilos. Within the placebo group, the teenagers gained about 3 p.c of their preliminary weight, about 5 kilos. The typical change in BMI (physique mass index) was -16 p.c within the remedy group and +0.6 p.c within the placebo group.

Within the remedy group, 73 p.c misplaced a minimum of 5 p.c of their weight, 62 p.c misplaced a minimum of 10 p.c, and 37 p.c misplaced a minimum of 20 p.c. Teenagers who obtained the remedy additionally had reductions in clinically necessary cardiovascular threat elements, together with smaller waist circumference, whole ldl cholesterol, and triglycerides, which the placebo group didn’t. Lastly, adolescents who obtained remedy reported enhancements in high quality of life measures of bodily consolation.

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